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Elson S. Floyd College of Medicine

Faculty Directory

BIN SHAN, M.D., PH.D.

Assistant Professor

Education

Ph.D., Tulane University
MD Equivalent, Central South University Xiangya School of Medicine

Additional Training

Tulane University School of Medicine, Postdoctoral research

Fellowships

NIH NRSA postdoctoral fellowship

Teaching

I teach Cell Physiology for first-year medical students. I currently advise two visiting scholars in my laboratory in the College of Medical Sciences.

Research

My laboratory focuses on the molecular mechanisms that promote pulmonary fibrosis and lung tumorigenesis. We investigate histone deacetylase 6-mediated lysine deacetylation and non-coding RNA-regulated gene expression in response to fibrogenic mediators identified in pulmonary fibrosis and lung cancer. We study how these two mechanisms regulate epithelial-mesenchymal transition (EMT) and acinar morphogenesis, a differentiation feature of lung alveolar epithelial cells. We use three-dimensional organotypic culture to recapitulate basement membrane support and to model epithelial morphogenesis.

Positions

Assistant Professor, College of Medical Sciences, WSU Spokane

Honors

2005 – 2006: NIH NRSA Postdoctoral Fellowship

2002: Travel Award for Keystone Symposia, Conference of Chromatin Structure and Activity

Selected Publications

  1. Loewen G, Jayawickramarajah J, Zhuo Y, Shan B.  lncRNA HOTAIR as a Novel Promoter of Lung Cancer Progression.  (invited review submitted for J Hematol Oncol)
  2. Zhuang Y, Nguyen HT, Burow ME, Zhuo Y, El-Dahr SS, Yao X, Cao S, Flemington EK, Nephew KP, Fang F, Collins-Burow B, Rhodes LV, Yu Q, Shan B.  Elevated expression of long intergenic non-coding RNA HOTAIR in a basal-like variant of MCF-7 breast cancer cells.  (accepted for publication in Molecular Carcinogenesis)
  3. Loewen G, Zhuo Y, Zhuang Y, Jayawickramarajah J, Shan B.  lincRNA HOTAIR as a Novel Promoter of Cancer Progression.  J Cancer Res Updates. 2014 Aug 12;3(3):134-140.
  4. Zhuang Y, Wang X, Nguyen HT, Cui X, Fewell C, Flemington EK, Shan B.  Induction of Long Intergenic Non-coding RNA HOTAIR in Lung Cancer Cells by Type I Collagen.  J Hematol Oncol. 2013 May 13;6:35. PubMed PMID: 23668363.
  5. Nguyen HT, Zhuang Y, Sun L, Kantrow SP, Kolls JK, You Z, Zhuo Y, Shan B.  Src-mediated morphology transition of lung cancer cells in three-dimensional organotypic culture.  Cancer Cell Int. 2013 Feb 14;13(1):16. PubMed PMID: 23409704.
  6. Li C, Nguyen HT, Zhuang Y, Lin Z, Flemington EK, Zhuo Y, Kantrow SP, MorrisGF, Sullivan DE, Shan B.  Comparative profiling of miRNA expression of lung adenocarcinoma cells in two-dimensional and three-dimensional cultures. Gene. 2012 Dec 15;511(2):143-50. PubMed PMID: 23036707.
  7. Nguyen HT, Li C, Lin Z, Flemington EK, Zhuang Y, Burow ME, Lin Y, Shan B.  The microRNA expression associated with morphogenesis of breast cancer cells in three-dimensional organotypic culture.  Oncol Rep. 2012 Jul;28(1): 117-126. PubMed PMID: 22576799.
  8. Li C, Nguyen HT, Zhuang Y, Lin Y, Flemington EK, Guo W, Guenther J, Burow ME, Morris GF, Sullivan D, Shan B.  Post-transcriptional Up-regulation of miR-21 by Type I Collagen.  Mol Carcinog. 2011 Jul;50(7):563-70. PubMed PMID: 21647970.
  9. Saito S, Lasky JA, Guo W, Nguyen HT, Mai A, Danchuk FS, Sullivan DE, Shan B.  Pharmacological Inhibition of HDAC6 Attenuates Endothelial Barrier Dysfunction Induced by Thrombin.  Biochem Biophys Res Commun.2011 May 20;408(4):630-34 PubMed PMID: 21531207.
  10. Shan B, Hagood JS, Zhuo Y, Nguyen HT, MacEwen M, Morris GF, Lasky JA.  Thy-1 Attenuates TNF-a-activated Gene Expression in Mouse Embryonic Fibroblasts via Src Family Kinase.  PLoS One.2010 Jul 19;5(7):e11662. PubMed PMID: 20657842
  11. Zhuang Y, Nguyen HT, Lasky JA, Cao S, Li C, Hu J, Guo X, Burow ME, Shan B.  Requirement of a Novel Splicing Variant of Human Histone Deacetylase 6 for TGF-b1-mediated Gene Activation.  Biochem Biophys Res Commun. 2010 Feb 19;392(4):608-13. PubMed PMID: 20102703.
  12. Shan B*, Yao TP, Nguyen HT, Zhuo Y, Klingsberg RC, Palmer M, Holder K, Levy DR, Lasky JA.  Requirement of Histone Deacetylase 6 for TGF-b1-induced Epithelial-Mesenchymal Transition.  J Biol Chem. 2008 Jul 25;283(30):21065-73. PubMed PMID: 20102703. (* denotes correspondence author)
  13. Shan B, Morris CA, Zhuo Y, Shelby BD, Levy DR, Lasky JA.  Activation of proMMP-2 and Src by HHV8 vGPCR in Human Pulmonary Arterial Endothelial Cells.  J Mol Cell Cardiol. 2007 Mar; 42(3):517-25. PubMed PMID: 17188706. (Comment in Human herpes virus-8-encoded chemokine receptor homologues: novel mechanistic link for pulmonary arterial hypertension? [J Mol Cell Cardiol. 2007])
  14. Shan B, Morris GF.  Binding sequence-dependent regulation of the human Proliferating Cell Nuclear Antigen promoter by p53.  Exp Cell Res.2005 Apr 15;305(1):10-22. PubMed PMID:15777783.
  15. Shan B, Zhuo Y, Chin D, Morris CA, Morris GF and Lasky JA.  CDK9 is required for Tumor Necrosis Factor-a Stimulated MMP-9 Expression in Human Lung Adenocarcinoma Cells.  J Biol Chem. 2005 Jan 14; 280(2):1103-11. PubMed PMID: 15528190.
  16. Shan B, Xu J, Zhuo Y, Morris CA, Morris GF.  Induction of p53-dependent activation of the human proliferating cell nuclear antigen gene in chromatin by ionizing radiation.  J Biol Chem. 2003 Nov 7; 278(45):44009-17. PubMed PMID: 12947108.

More publications

bin-shan
BIN SHAN, M.D., PH.D.

Assistant Professor
bin.shan@wsu.edu
509-358-7813