JONATHAN WISOR, PH.D.
Dr. Wisor received a Bachelor of Science degree in psychology from Pennsylvania State University. He received a PhD in Neuroscience from the University of California, Los Angeles. He then served as a postdoctoral fellow and subsequently as a research associate at Stanford University School of Medicine. From 2004 through 2008 he was a staff scientist at SRI International, a non-profit research institute in Menlo Park, California. He has served on the faculty of Washington State University and the WWAMI (Washington, Wyoming, Alaska, Montana, Idaho) Medical Education Program since December of 2008.
The Wisor Lab
The Wisor lab personnel: (L-R) Will Clegern (research technologist); Jonathan Wisor (principal investigator); Michelle Schmidt (research technologist); Janne Grønli (research assistant professor); Michael Rempe (adjunct professor)
Humans spend roughly one-third of their lives asleep. Sleep insufficiency has a number of negative effects on health and well-being. The function that is served by sleep and the mechanisms by which sleep insufficiency causes health problems are not well understood.
The purpose of my research program is to identify functional consequences of sleep and sleep loss within the nervous system.
My laboratory has received funding from the Department of Defense (Defense Advanced Research Projects Agency, Young Faculty Award) and the National Institute of Neurological Disorders and Stroke to apply molecular genetic and biochemical techniques in studies of the regulation of sleep.
These projects are aimed at characterizing the roles of genetic loci and discrete cell populations within the cerebral cortex in regulating sleep and sleep-related electroencephalographic wave forms. We use gene expression and protein profiling in microglial and neuronal cell populations to identify putative regulators of sleep. We use germ line targeted optogenetic constructs to modulate the activity of discrete cell types and measure the effects of these manipulations on sleep. Working with research partners, we perform studies on human subject populations to apply the findings of basic neurobiological studies to issues related to human health.
Selected Publications (click active titles for links)
Wisor JP, Rempe MJ, Schmidt MA, Moore ME, Clegern WC (2012) Sleep slow wave activity regulates cerebral glycolytic metabolism. Cerebral Cortex, in press PMID: 22767634.
Clegern WC, Schmidt MA, Moore ME, Wisor JP (2012) Simultaneous electroencephalography, real-time measurement of lactate concentration and optogenetic manipulation of neuronal activity in the rodent cerebral cortex.Journal of Visualized Experimentation, in press.
Jiang P, Franklin KM, Duncan MJ, O’Hara BF, Wisor JP (2012) Distinct phase relationships between suprachiasmatic molecular rhythms, cerebral cortex molecular rhythms and behavioral rhythms in early runner (CAST/EiJ) and nocturnal (C57BL/6J) mice. Sleep, in press.
Wisor JP, Schmidt MA (2012) Interleukin 1 receptor signaling mediates methamphetamine- and sleep deprivation-induced hypersomnolence.Neurosci Lett, 513(2):209-13 PMID: 22387068.
Wisor JP (2012) A metabolic-transcriptional network links sleep and cellular energetics in the brain. Pflugers Arch. Eur J Physiol, 463:15-22 PMID: 21927810.
Wisor JP, Clegern WC and Schmidt MA (2011) Toll-like receptor 4 is a regulator of monocyte and electroencephalographic responses to sleep loss.Sleep 34(10):1335-45 PMID: 21966065.
Wisor JP, Clegern WC and Schmidt MA (2011) Cerebral microglia mediate sleep/wake and neuroinflammatory effects of methamphetamine. Brain Behavior and Immunity, 25(4):767-76 PMID: 21333736.
Wisor JP and Clegern WC (2011) Quantification of short-term slow wave sleep homeostasis and its disruption by minocycline in the laboratory mouse.Neurosci Lett, 490(3):165-9 PMID: 21111032.
Krueger JM, Wisor JP (2011), Local use-dependent sleep, an introductionCurr Topics Med Chem 11:2390-1 PMID: 22181666.
Wisor JP et al., (2011) Sleep-active neuronal nitric oxide synthase-positive cells of the cerebral cortex: a local regulator of sleep? Curr Topics Med Chem11(19):2483-9 PMID: 21906016.
Gerashchenko D, Wisor JP, Kilduff TS (2011) Sleep-active cells in the cerebral cortex and their role in slow-wave activity, Sleep Biol Rhythms9(s1):71-77 PMID: 21625335.
Wisor JP et al., (2011) Evidence for neuroinflammatory and microglial changes in the cerebral response to sleep loss, Sleep 34(3):261-72 PMID: 21358843.
Jiang P, Striz M, Wisor JP and O’Hara BF (2011) Behavioral and genetic dissection of a mouse model for advanced sleep phase syndrome, Sleep34:39-48 PMID: 21203370.
Morairty SR, Wisor JP, Sinko W, Silveira K, Kilduff TS (2011) The wake-promoting effects of hypocretin-1 is attenuated in old rats Neurobiology of Aging, 32:1514-27 PMID: 19781813.
Oonk M, Davis CJ, Krueger JM, Wisor JP, Van Dongen HPA (2011) Investigating the Two-Trial Y-Maze as a Performance Assay for Sleep Deprivation Studies in C57BL/6 mice. Netherlands Sleep-Wake Organization Yearbook 2011 22: 72-75.
Thompson CL, Wisor JP, et al., (2010) Molecular anatomic signatures of sleep deprivation in the mouse brain, Front Neurosci. 4:165 PMID: 21088695.
JONATHAN WISOR, PH.D.