{"id":32900,"date":"2025-02-14T15:16:11","date_gmt":"2025-02-14T23:16:11","guid":{"rendered":"https:\/\/medicine.wsu.edu\/news\/?post_type=tribe_events&#038;p=32900"},"modified":"2025-02-27T08:20:09","modified_gmt":"2025-02-27T16:20:09","slug":"tmp-seminar-march11","status":"publish","type":"tribe_events","link":"https:\/\/medicine.wsu.edu\/news\/event\/tmp-seminar-march11\/","title":{"rendered":"Translational Medicine and Physiology Seminar Series"},"content":{"rendered":"<h2 data-pm-slice=\"1 1 []\">A\u03b242: A Jack of Many Troublesome Trades in Alzheimer\u2019s Disease<\/h2>\n<h3>March 11, 2025<br \/>\n12:10\u20131:00 P.M. PST<br \/>\nSAC 347 or via\u00a0<a href=\"https:\/\/wsu.zoom.us\/j\/91368483019?pwd=UbJ0vm04yzvpU7KE5B7q1P9iDNgx2Q.1&amp;from=addon\">Zoom<\/a><br \/>\nMeeting ID: 913 6848 3019<br \/>\nPasscode: 804433<\/h3>\n<p><strong>Speaker:<\/strong> Annalisa Scimemi, PhD<br \/>\nAssociate Professor in the Department of Biology at SUNY Albany<\/p>\n<p data-pm-slice=\"1 1 []\">Synapses are critical targets of Alzheimer\u2019s disease (AD), a highly prevalent neurodegenerative disease associated with accumulation of extracellular amyloid-\u03b2 peptides. Although amyloidosis and aggregation of the 42-amino acid amyloid-\u03b2 (A\u03b242) have long been considered pathogenic triggers for AD, clinical evidence linking high levels of soluble A\u03b242 with normal cognition challenges this hypothesis. To resolve this conundrum on the role of A\u03b242 in regulating synaptic activity, we used a viral approach to trigger extracellular accumulation of A\u03b242 and spatial memory impairment. We will discuss the effects that this peptide exerts on synaptic function in the mouse hippocampus.<\/p>\n<div class=\"tribe-events-single-event-description tribe-events-content\">\n<div id=\"post-31871\" class=\"post-31871 tribe_events type-tribe_events status-publish has-post-thumbnail hentry tribe_events_cat-research tribe_events_cat-translational-medicine-and-physiology cat_research cat_translational-medicine-and-physiology\">\n<div class=\"tribe-events-single-event-description tribe-events-content\">\n<div class=\"tribe-events-single-event-description tribe-events-content\">\n<p>For more information contact\u00a0<a href=\"mailto:michelle.r.sanchez@wsu.edu\">Michelle Sanchez<\/a>.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"tribe-events tribe-common\">\n<div class=\"tribe-events-c-subscribe-dropdown__container\"><\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Join us as Annalisa Scimemi, PhD, an Associate Professor in the Department of Biology at SUNY Albany, present on A\u03b242: A Jack of Many Troublesome Trades in Alzheimer\u2019s Disease<\/p>\n","protected":false},"author":34189,"featured_media":32901,"comment_status":"open","ping_status":"closed","template":"","meta":{"_wsuwp_accessibility_report":[],"_tribe_events_status":"","_tribe_events_status_reason":""},"tags":[],"tribe_events_cat":[66],"wsuwp_university_location":[],"wsuwp_university_org":[],"event_city":"Spokane","event_state":"WA","event_venue":"SAC 347","event_organizer":"","event_organizer_email":"","event_organizer_phone":"","event_organizer_website":"","event_website":"https:\/\/wsu.zoom.us\/j\/91368483019?pwd=UbJ0vm04yzvpU7KE5B7q1P9iDNgx2Q.1&#038;from=addon","event_cost":"","event_excerpt":"A\u03b242: A Jack of Many Troublesome Trades in Alzheimer\u2019s Disease\nMarch 11, 2025\n12:10\u20131:00 P.M. PST\nSAC 347 or via\u00a0Zoom\nMeeting ID: 913 6848 3019\nPasscode: 804433\nSpeaker: Annalisa Scimemi, PhD\nAssociate Professor in the Department of Biology at SUNY Albany\nSynapses are critical targets of Alzheimer\u2019s disease (AD), a highly prevalent neurodegenerative disease associated with accumulation of extracellular amyloid-\u03b2 peptides. Although amyloidosis and aggregation of the 42-amino acid amyloid-\u03b2 (A\u03b242) have long been considered pathogenic triggers for AD, clinical evidence linking high levels of soluble A\u03b242 with normal cognition challenges this hypothesis. To resolve this conundrum on the role of A\u03b242 in regulating synaptic activity, we used a viral approach to trigger extracellular accumulation of A\u03b242 and spatial memory impairment. We will discuss the effects that this peptide exerts on synaptic function in the mouse hippocampus.\n\n\n\n\nFor more information contact\u00a0Michelle Sanchez.","start_date":"2025-03-11 12:10:00","end_date":"2025-03-11 13:00:00","_links":{"self":[{"href":"https:\/\/medicine.wsu.edu\/news\/wp-json\/wp\/v2\/events\/32900"}],"collection":[{"href":"https:\/\/medicine.wsu.edu\/news\/wp-json\/wp\/v2\/events"}],"about":[{"href":"https:\/\/medicine.wsu.edu\/news\/wp-json\/wp\/v2\/types\/tribe_events"}],"author":[{"embeddable":true,"href":"https:\/\/medicine.wsu.edu\/news\/wp-json\/wp\/v2\/users\/34189"}],"replies":[{"embeddable":true,"href":"https:\/\/medicine.wsu.edu\/news\/wp-json\/wp\/v2\/comments?post=32900"}],"version-history":[{"count":3,"href":"https:\/\/medicine.wsu.edu\/news\/wp-json\/wp\/v2\/events\/32900\/revisions"}],"predecessor-version":[{"id":33009,"href":"https:\/\/medicine.wsu.edu\/news\/wp-json\/wp\/v2\/events\/32900\/revisions\/33009"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medicine.wsu.edu\/news\/wp-json\/wp\/v2\/media\/32901"}],"wp:attachment":[{"href":"https:\/\/medicine.wsu.edu\/news\/wp-json\/wp\/v2\/media?parent=32900"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medicine.wsu.edu\/news\/wp-json\/wp\/v2\/tags?post=32900"},{"taxonomy":"tribe_events_cat","embeddable":true,"href":"https:\/\/medicine.wsu.edu\/news\/wp-json\/wp\/v2\/tribe_events_cat?post=32900"},{"taxonomy":"wsuwp_university_location","embeddable":true,"href":"https:\/\/medicine.wsu.edu\/news\/wp-json\/wp\/v2\/wsuwp_university_location?post=32900"},{"taxonomy":"wsuwp_university_org","embeddable":true,"href":"https:\/\/medicine.wsu.edu\/news\/wp-json\/wp\/v2\/wsuwp_university_org?post=32900"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}