TED CHAUVIN, PhD
PhD Washington State University (Genetics and Cell Biology)
MS and BS Northern Illinois University
Dr. Chauvin is the course chair for Biochemistry for first-year medical students in Spokane. He has mentored undergraduate students from Gonzaga University, Whitworth University, and Whitman College. In addition, he has served as a mentor for medical students in the University of Washington School of Medicine’s Medical Student Research Training Program.
Male Reproduction/Sperm Maturation
Successful fertilization of the egg requires sperm capable of motility and possessing the ability to undergo an acrosome-reaction upon contact with the egg; defects in these sperm functions contribute significantly to male infertility. Sperm gain the ability to swim and to fertilize an oocyte during their transit through the epididymis. Epididymal sperm maturation is characterized by changes in both protein and lipid composition of the sperm. The research in my laboratory investigates the molecular function of sperm maturation with specific focus on how lipid synthesis and maintenance occur. The laboratory employs various molecular biology and biochemical techniques to investigate the maturation process with hopes of understanding male infertility and possibly finding a contraceptive target.
2013 WSU Spokane research seed grant: Lipid Function in Epididymal Sperm
Chauvin T.R, Xie F., Liu, T., Nicora C.D., Yang F., Camp II, D.G., Smith, R.D., and Roberts, K. A Systematic Analysis of a Deep Mouse Epididymal Sperm Proteome. Biology of Reproduction 2012; 87:141, 1-8
Chauvin, T.R., Herndon, M.K. and Nilson, J.H. Cold-Shock-Domain Protein A (CSDA) Contributes Post-Transcriptionally to Gonadotropin-Releasing Hormone-Regulated Expression of Egr1 and Indirectly to Lhb. Biology of Reproduction 2011; 86:53, 1-10
Chauvin, T.R. and Griswold, M.D. Identification of Regulated Genes in the Murine Epididymis Using Oligonucleotide Microarrays. Biology of Reproduction 2004; 71:560-569.
Chauvin, T.R. and Griswold, M.D. Characterization of the Expression and Regulation of Genes Necessary for myo-Inositol Biosynthesis and Transport in the Seminiferous Epithelium. Biology of Reproduction 2004; 70:744-751.