Yiyong (Ben) Liu, PhD
Education and Training
PhD in Biochemistry and Molecular Biology, East Tennessee State University
Postdoctoral Training, HHMI, Duke University Medical Center
We study stress responses and aging using the Caenorhabditis elegans model and the human cell models. Living organisms are constantly challenged by endogenous insults as well as environmental agents. Mounting appropriate stress responses to counter these attacks is key to health and longevity. Our research focuses on DNA damage responses, immune responses, and how these responses relate to aging and neurodegeneration diseases.
Sellegounder D, Liu Y, Wibisono P, Chen C, Leap D, and Sun J. Neuronal GPCR NPR-8 regulates C. elegans defense against pathogen infection. Science Advances 2019 (In press).
Sellegounder D*, Yuan CH*, Wibisono P, Liu Y, and Sun J. Octopaminergic signaling mediates neural regulation of innate immunity in Caenorhabditis elegans. mBio 2018, 9(5). *co-first author.
Liu Y and Sun J. G protein-coupled receptors mediate neural regulation of innate immune responses in Caenorhabditis elegans. Receptors & Clinical Investigation 2017, 4: e1543.
Liu Y, Sellegounder D, and Sun J. (2016) Neuronal GPCR OCTR-1 regulates innate immunity by controlling protein synthesis in Caenorhabditis elegans. Scientific Reports, 6, 36832-36845.
Sun J, Liu Y, and Aballay A. (2012) Organismal regulation of XBP-1-mediated unfolded protein response during development and immune activation. EMBO Reports, 13, 855-860.
Liu Y, Kadyrov FA, and Modrich P. (2011) PARP-1 enhances mismatch dependence of 5’-directed excision in human mismatch repair. DNA Repair, 10, 1145-1153.
van Oers JM, Rao S, Werling U, Liu Y, Genschel J, Hou H Jr, Sellers RS, Modrich P, Scharff MD, and Edelmann W. (2010) PMS2 endonuclease activity has distinct biological functions and is essential for genome maintenance. Proc Natl Acad Sci USA, 107, 13384-13389.
Liu Y, Fang Y, Shao H, Lindsey-Boltz L, Sancar A, and Modrich P. (2010) Interactions of human mismatch repair proteins MutSα and MutLα with proteins of the ATR-Chk1 checkpoint pathway. J Biol Chem, 285, 5974-5982.
Liu Y, Wang Y, Rusinol A, Sinensky M, Liu J, Shell SM, and Zou Y. (2008) Involvement of xeroderma pigmentosum group A (XPA) in progeria arising from defective maturation of prelamin A. FASEB J, 22, 603-611.
Liu Y and Zou Y. (2007) New insights into the roles of XPA and RPA in DNA repair and DNA damage responses. Current Chemical Biology, 1, 151-160.
Wu X, Shell SM, Liu Y, and Zou Y. (2007) ATR-dependent checkpoint modulates XPA nuclear import in response to UV irradiation. Oncogene, 26, 757-764.
Liu Y, Rusinol A, Sinensky M, Wang Y, and Zou Y. (2006) DNA damage responses in progeroid syndromes arising from defective maturation of prelamin A. J Cell Sci, 119, 4644-4649.
Zou Y, Liu Y, Wu X and Shell S.M. (2006) Functions of human replication protein A (RPA): From DNA replication to DNA damage and stress responses. J Cell Physiol, 208, 267-273.
Liu Y, Kvaratskhelia M, Hess S, Qu Y, and Zou Y. (2005) Modulation of replication protein A function by its hyperphosphorylation-induced conformational change involving DNA binding domain B. J Biol Chem, 280, 32775-32783.
Liu Y, Yang Z, Utzat CD, Liu Y, Geacintov NE, Basu AK, and Zou Y. (2005) Interactions of human replication protein A with single-stranded DNA adducts. Biochem J, 385, 519-526.
Liu Y, Liu Y, Yang Z, Utzat C, Wang G, Basu AK, and Zou Y. (2005) Cooperative interaction of human XPA stabilizes and enhances specific binding of XPA to DNA damage. Biochemistry, 44, 7361-7368.