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Faculty and Staff Directory

YOOL LEE, PhD

Assistant Professor

Education

PhD, Biological Sciences, Seoul National University , South Korea
MS, Biological Sciences, Seoul National University, South Korea
BS, Biological Sciences, Seoul National University, South Korea

Academic Positions

2016 – 2020: Research associate, (PI: Amita Sehgal, PhD) in Department of Neuroscience, Perelman School of Medicine, University of Pennsylvania

2011 – 2016: Postdoctoral researcher, (PI: John Hogenesch, PhD) in Department of Pharmacology, Perelman School of Medicine, University of Pennsylvania

2010-2011: Postdoctoral researcher, (PI: Kyungjin Kim, PhD) in School of Biological Sciences, Seoul National University, South Korea

Research Interests

  • Investigating the molecular, cellular, and physiological mechanisms of circadian rhythms in behavior and physiology (Chrono-physiology)
  • Investigating the molecular and cellular impact of circadian disruptions on cancer and neurodegenerative pathogenesis (Chrono-pathology)
  • Therapeutic applications of circadian rhythm for the treatment of cancer and neurodegenerative diseases (Chrono-therapy)

Awards

2008 Grant award by National Research Foundation of Korea

Publications

Lee Y, Fong SY, Shon J, Zhang S, Brooks R, Lahens NF, Chen D, Dang CV, Field JM, Sehgal A. 2021. Time-of-day specificity of anti-cancer drugs may be mediated by circadian regulation of the cell cycle. Science Advances. 7, eabd2645. doi: 10.1126/sciadv.abd2645. PMID: 33579708.

Lee Y, Shen Y, Francey LJ, Ramanathan C, Sehgal A, Liu AC, Hogenesch JB. The NRON complex controls circadian clock function through regulated PER and CRY nuclear translocation. Sci Rep. 2019 Aug 15;9(1):11883. doi: 10.1038/s41598-019-48341-8. PubMed PMID: 31417156; PubMed Central PMCID: PMC6695496.

Lee Y, Lahens NF, Zhang S, Bedont J, Field JM, Sehgal A. G1/S cell cycle regulators mediate effects of circadian dysregulation on tumor growth and provide targets for timed anticancer treatment. PLoS Biol. 2019 Apr;17(4):e3000228. doi: 10.1371/journal.pbio.3000228. eCollection 2019 Apr. PubMed PMID: 31039152; PubMed Central PMCID: PMC6490878.

Bai L, Lee Y, Hsu CT, Williams JA, Cavanaugh D, Zheng X, Stein C, Haynes P, Wang H, Gutmann DH, Sehgal A. A Conserved Circadian Function for the Neurofibromatosis 1 Gene. Cell Rep. 2018 Mar 27;22(13):3416-3426. doi: 10.1016/j.celrep.2018.03.014. PubMed PMID: 29590612; PubMed Central PMCID: PMC5898822.

Havekes R, Park AJ, Tolentino RE, Bruinenberg VM, Tudor JC, Lee Y, Hansen RT, Guercio LA, Linton E, Neves-Zaph SR, Meerlo P, Baillie GS, Houslay MD, Abel T. Compartmentalized PDE4A5 Signaling Impairs Hippocampal Synaptic Plasticity and Long-Term Memory. J Neurosci. 2016 Aug 24;36(34):8936-46. doi: 10.1523/JNEUROSCI.0248-16.2016. PubMed PMID: 27559174; PubMed Central PMCID: PMC4995304.

Lee Y, Chun SK, Kim K. Sumoylation controls CLOCK-BMAL1-mediated clock resetting via CBP recruitment in nuclear transcriptional foci. Biochim Biophys Acta. 2015 Oct;1853(10 Pt A):2697-708. doi: 10.1016/j.bbamcr.2015.07.005. Epub 2015 Jul 9. PubMed PMID: 26164627.

Lee Y, Jang AR, Francey LJ, Sehgal A, Hogenesch JB. KPNB1 mediates PER/CRY nuclear translocation and circadian clock function. Elife. 2015 Aug 29;4. doi: 10.7554/eLife.08647. PubMed PMID: 26319354; PubMed Central PMCID: PMC4597257.

Park I, Lee Y, Kim HD, Kim K. Effect of Resveratrol, a SIRT1 Activator, on the Interactions of the CLOCK/BMAL1 Complex. Endocrinol Metab (Seoul). 2014 Sep;29(3):379-87. doi: 10.3803/EnM.2014.29.3.379. Epub 2014 Sep 25. PubMed PMID: 25309798; PubMed Central PMCID: PMC4192820.

Anafi RC, Lee Y, Sato TK, Venkataraman A, Ramanathan C, Kavakli IH, Hughes ME, Baggs JE, Growe J, Liu AC, Kim J, Hogenesch JB. Machine learning helps identify CHRONO as a circadian clock component. PLoS Biol. 2014 Apr;12(4):e1001840. doi: 10.1371/journal.pbio.1001840. eCollection 2014 Apr. PubMed PMID: 24737000; PubMed Central PMCID: PMC3988006.

Musiek ES, Lim MM, Yang G, Bauer AQ, Qi L, Lee Y, Roh JH, Ortiz-Gonzalez X, Dearborn JT, Culver JP, Herzog ED, Hogenesch JB, Wozniak DF, Dikranian K, Giasson BI, Weaver DR, Holtzman DM, Fitzgerald GA. Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration. J Clin Invest. 2013 Dec;123(12):5389-400. doi: 10.1172/JCI70317. Epub 2013 Nov 25. PubMed PMID: 24270424; PubMed Central PMCID: PMC3859381.

Lee Y, Kim K. Posttranslational and epigenetic regulation of the CLOCK/BMAL1 complex in the mammalian. Animal cells and systems. 2012; 16(1):1-10. doi: 10.1080/19768354.2011.603749.

Lee Y, Lee J, Kwon I, Nakajima Y, Ohmiya Y, Son GH, Lee KH, Kim K. Coactivation of the CLOCK-BMAL1 complex by CBP mediates resetting of the circadian clock. J Cell Sci. 2010 Oct 15;123(Pt 20):3547-57. doi: 10.1242/jcs.070300. PubMed PMID: 20930143.

Lee J, Lee Y, Lee MJ, Park E, Kang SH, Chung CH, Lee KH, Kim K. Dual modification of BMAL1 by SUMO2/3 and ubiquitin promotes circadian activation of the CLOCK/BMAL1 complex. Mol Cell Biol. 2008 Oct;28(19):6056-65. doi: 10.1128/MCB.00583-08. Epub 2008 Jul 21. PubMed PMID: 18644859; PubMed Central PMCID: PMC2546997.

Eun B, Lee Y, Hong S, Kim J, Lee HW, Kim K, Sun W, Kim H. Hes6 controls cell proliferation via interaction with cAMP-response element-binding protein-binding protein in the promyelocytic leukemia nuclear body. J Biol Chem. 2008 Feb 29;283(9):5939-49. doi: 10.1074/jbc.M707683200. Epub 2007 Dec 26. PubMed PMID: 18160400.

A complete list of published works can be found here.

Yool Lee, Biomedical Sciences, Spokane, Yool Lee Headshot
YOOL LEE, PhD
Assistant Professor
yool.lee@wsu.edu
509-368-6974