Hans Haverkamp, PhD

• University of Vermont, Vermont Lung Center, Post-doctoral fellowship
• University of Wisconsin-Madison, PhD
• Northern Arizona University, MS
• Ithaca College, BS

• Associate Professor of Nutrition & Exercise Physiology, August 2018-current
  • Washington State University-Health Sciences Spokane
• Associate Professor of Exercise Physiology, August 2013-May 2018
  • Vermont State University-Johnson
• Assistant Professor of Exercise Physiology, August 2007-May 2013
  • Vermont State University-Johnson
• Post-doctoral research fellow, April 2005-July 2007
  • Vermont Lung Center, University of Vermont

Dr. Haverkamp is an exercise physiologist with particular expertise in the pulmonary system responses to exercise in health and disease. Currently, Dr. Haverkamp's lab has two ongoing areas of research.

Research area #1: Dr. Haverkamp's primary research interest investigates the factors that control airway function during and after exercise in adults with asthma. This research is dynamic and integrative, emphasizing whole-body exercise, respiratory system function, airway biology and pathophysiology of asthma.

Asthma is one of the most common chronic clinical conditions worldwide. The societal burden of asthma is profound. It is responsible for enormous healthcare costs, significant days lost from work and school, and decreased quality of life. Asthmatics are less likely to participate in regular exercise, thus missing out on the health benefits of regular physical activity. Furthermore, the lung function response to exercise in the asthmatic is complex and not understood. For example, depending on the exercise intensity and duration, the airways may either dilate or constrict during the exercise. Because of this variable airway response, exercise advice by the medical and athletic communities is less precise than it could, or should, be. Dr. Haverkamp’s research seeks to clarify the physiological factors that determine such variable airway function in the asthmatic. Current projects are particularly focused on understanding the role of lung volume and breathing mechanics in determining airway diameter during exercise. Related studies are investigating if increased breathing volumes and lung stretch after exercise prevent exercise-induced asthma. Future work will integrate other determinants of airway function, such as neural control and the influence of biological mediators released from airway cells.

Research area #2: Dr. Haverkamp's second area of research seeks to understand the causes and consequences of exercise overtraining in healthy adults. Overtraining occurs when the training stimulus is not properly balanced with adequate rest/recovery. Over time, this imbalance will lead to reduced exercise performance, generalized fatigue, poor mood state, and sleep disturbances. We currently have ongoing studies designed to induce a mild form of overtraining in healthy adults, and to determine the causes and outcomes of the overtraining. This research requires a holistic and integrative analysis of the exercise responses and also applies modern biological techniques to provide novel insights into overtraining. For example, we are completing proteomics analysis on participants' blood and also analyzing sleep behavior using actigraphy.

 

Dr. Haverkamp's google scholar page: Google Scholar

1.      H.C. Haverkamp*, P. Luu, T. DeCato, G. Petrics. Artificial Neural Network Identification of Expiratory Flow-Limitation in Adults. Scientific Reports 2023 13:17247. http://doi.org/10.1038/s41598-023-4431-z.

2.      O. Klimenko⁺, P. Luu⁺, P. Dominelli, N. Noggle, G. Petrics, H.C. Haverkamp*. Effect of exercise-induced bronchoconstriction on the configuration of the maximal expiratory flow-volume curve in adults with asthma. Physiol Reports 2023;11:e15614. https://doi.org/10.14814/phy2.15614.

3.      R. Bindler, H.C. Haverkamp, H. O’Flanagan, J. Whicker, A.G. Rappold, V. Walden et al. Feasibility and acceptability of home monitoring with portable spirometry in young adults with asthma. J Asthma 2023; 60(7): 1474-1479. DOI: 10.1080/02770903.2022.2160345. PMID: 36525469.

4.      T.W. DeCato, H.C. Haverkamp, T.G. Gooding, D.S. Collingridge, M.J. Hegewald. Variability in cardiopulmonary exercise testing biologic controls. Resp Care 68(1):38-43, 2023. DOI: 10.4187/respcare.10022.

5.      M.J. Rossman, G. Petrics, A. Klansky, K. Craig, C. Irvin, H.C. Haverkamp*. Exercise induced bronchodilation equalizes exercise ventilatory mechanics despite variable baseline airway function in asthma. Med Sci Sports Exerc 54(2): 258-66, 2022. DOI: 10.1249/MSS.0000000000002793.

6.      Miller, K. Thompson, C. Pavlenco, V. Mettu, H.C. Haverkamp, S. Skaufel, A. Basit, B. Prasad, J. Larsen. The effect of daily methylsulfonylmethane consumption on high-density lipoprotein cholesterol in healthy overweight and obese adults: a randomized controlled trial. Nutrients 13(10): 3620, 2021. DOI: 10.3390/nu13103620.

7.      J. Postma, Odom-Maryon, T., Rappold, A., H.C. Haverkamp, Amiri, S., Bindler, R., Whicker, J., Walden, V. Promoting risk reduction among young adults with asthma during wildfire smoke. Public Health Nursing 2021: 1-10. Manuscript ID: PHN-21-0438.

8.      H.C. Haverkamp*, S. McPherson, D. Kaminsky, C. Irvin. Spirometric response to bronchodilator and eucapnic voluntary hyperpnea in adults with asthma. Resp Care 66(7), 2021. DOI: 10.4187/respcare.08421.

9.      E. Towers, A. Morrison-Taylor, J. Demar, A. Klansky, K. Craig, H.C. Haverkamp*. Acute and daily effects of repeated voluntary hyperpnea on pulmonary function in healthy adults. Eur J Appl Physiol 120(3): 625-633, 2020. DOI 10.1007/s00421-020-04302-y.

10.  A. Klansky, C. Irvin, A. Morrison-Taylor, S. Ahlstrand, D. Labrie, H.C. Haverkamp*. No effect of elevated operating lung volumes on airway function during variable workrate exercise in asthmatic humans. J Appl Physiol 121: 89-100, 2016.

11.  P.B. Dominelli, Y. Molgat-Seon, G. Foster, G. Dominelli, H.C. Haverkamp, W. Henderson, W. Sheel. Quantifying the shape of maximal flow-volume curves in healthy humans and asthmatic patients. Respir Physiol Neurobiol 220: 46-53, 2016.

12.  P.B. Dominelli, G. Foster, J. Guenette, H.C. Haverkamp, N. Eves, G. Dominelli, W. Henderson, D. O’Donnell, W. Sheel. Quantifying the shape of the maximal expiratory flow-volume curve in mild COPD. Respir Physiol Neurobiol 219: 30-35, 2015.

13.  M.J. Rossman, S.K. Nader, D. Berry, F. Orsini, A. Klansky, H.C. Haverkamp*. Effects of altered airway function on exercise ventilation in asthmatic adults. Med Sci Sports Exerc 46(6): 1104-1113, 2013.

14.  E.P. Riesenfeld, M.J. Sullivan, J.A. Thompson-Figueroa, H.C. Haverkamp, L.K. Lundblad, J.H.T. Bates, and C.G. Irvin. Inhaled salmeterol and/or fluticasone alter structure/function in a murine model of allergic airways disease. Resp Research 11:22, 2010.

15.  A.T. Lovering, H.C. Haverkamp, L.M. Romer, J. Hokanson, and M.W. Eldridge. Transpulmonary passage of 99mTc macroaggregated albumin in healthy humans at rest and during maximal exercise. J Appl Physiol 106(6): 1986-1992, 2009.

16.  A. Cojocaru, C.G. Irvin, H.C. Haverkamp, and J.H.T. Bates. Computational assessment of airway wall stiffness in vivo in allergically inflamed mouse models of asthma. J Appl Physiol 104(6): 1601-1610, 2008.

17.  A.T. Lovering, L.M. Romer, H.C. Haverkamp, D.F. Pegelow, J. Hokanson and M.W. Eldridge. Intrapulmonary shunting and pulmonary gas exchange in healthy humans during normoxic and hypoxic exercise. J Appl Physiol 104(5): 1418-1425, 2008.

18.  H.C. Haverkamp* and L.K. Lundblad. Commentary on “The role of the large airways on smooth muscle contraction in asthma.” J Appl Physiol 103(4): 1457-1458, 2007.

19. J.H. Bates, A. Cojocaru, H.C. Haverkamp, L.M. Rinaldi, and C.G. Irvin. The synergistic interactions of allergic lung inflammation and intra-tracheal cationic protein. Am J Respir Crit Care Med 177(3): 261-268, 2008.

20. H.C. Haverkamp*, J.A. Dempsey, D.F. Pegelow, J.D. Miller, L.M. Romer, M. Santana, and M.E. Eldridge. Treatment of airway inflammation improves pulmonary gas exchange and performance during exercise in habitually active asthmatic subjects. J Allergy Clin Immunol 120(1): 39-47, 2007.

21. A.T. Lovering, L.M. Romer, H.C. Haverkamp, J.S. Hokanson, and M.W. Eldridge. Case report: excessive gas exchange impairment during exercise in a subject with a history of bronchopulmonary dysplasia and high altitude pulmonary edema. High Altitude Med & Biol 8(1): 62-7, 2007.

22. L.M. Romer, J.D. Miller, H.C. Haverkamp, D.F. Pegelow, and J.A. Dempsey. Inspiratory muscles do not limit maximal incremental exercise performance in trained subjects. Respir Physiol and Neurobiol 156(3): 353-61, 2007.

23. S. Wagers, H.C. Haverkamp, J. Bates, R. Norton, J. Thompson-Figueroa, M. Sullivan, C. Irvin. Intrinsic and antigen induced airway hyperresponsiveness are the result of diverse physiologic mechanisms. J Appl Physiol 102(1): 221-30, 2007.

24. L.M. Romer, M. Amann, H.C. Haverkamp, A.T. Lovering, D.F. Pegelow, and J.A. Dempsey. Effect of acute severe hypoxia on peripheral fatigue and endurance capacity in healthy humans. Am J Physiol Regul Integr Comp Physiol 292(1): R598-606, 2007.

25. L.M. Romer, A.T. Lovering, H.C. Haverkamp, D.F. Pegelow, and J.A. Dempsey. Effect of inspiratory muscle work on peripheral fatigue of locomotor muscles in healthy humans. J Physiol 571(pt 2):425-39, 2006.

26. L.M. Romer, H.C. Haverkamp, A.T. Lovering, D.F. Pegelow, and J.A. Dempsey. Effect of exercise-induced arterial hypoxemia on quadriceps muscle fatigue in healthy humans. Am J Physiol Regul Integr Comp Physiol 290(2): R365-75, 2006.

27. H.C. Haverkamp*, J.A. Dempsey, J.D. Miller, L.M. Romer, D.F. Pegelow, J.R. Rodman, and M.W. Eldridge. Gas exchange during exercise in habitually active asthmatic subjects. J Appl Physiol 99(5): 1938-50, 2005.

28. H.C. Haverkamp*, J.A. Dempsey, J.D. Miller, L.M. Romer, A.T. Lovering, and M.W. Eldridge. Repeat exercise normalizes the gas exchange impairment induced by a previous exercise bout in asthmatics. J Appl Physiol 99(5): 1843-52, 2005.

29. M.W. Eldridge, J.A. Dempsey, H.C. Haverkamp, A.T. Lovering, and J.S. Hokanson. Exercise-induced intrapulmonary arteriovenous shunting in healthy humans. J Appl Physiol 97: 797-805, 2004.

30. H.C. Haverkamp & Jerome A. Dempsey. On the normal variability of gas exchange efficiency during exercise: does sex matter? J Physiol 557(2): 345, 2004.

31. H.C. Haverkamp*, J.D. Miller, J.R. Rodman, L.M. Romer, D.F. Pegelow, M. Santana, and J.A. Dempsey. Extrathoracic obstruction and hypoxemia occurring during exercise in a competitive female cyclist. Chest 124: 1602-1605, 2003.

32. A.J. Rice, H. Nakayama, H.C. Haverkamp, D.F. Pegelow, J.B. Skatrud, and J.A. Dempsey. Controlled vs. assisted mechanical ventilation effects on respiratory motor output in sleeping humans. Am J Resp Crit Care Med 168:92-101, 2003.

33. T.J. Wetter, Z. Xiang, D.A. Sonetti, H.C. Haverkamp, A.J. Rice, A.A. Abbasi, K.C. Meyer, and J.A. Dempsey. Role of lung inflammatory mediators as a cause of exercise-induced arterial hypoxemia in young male and female athletes. J Appl Physiol 93: 116-126, 2002.

34. H.C. Haverkamp*, M. Metelits, J. Hartnett, K. Olsson, and J.R. Coast. Pulmonary function subsequent to expiratory muscle fatigue in healthy humans. Int J Sports Med 22: 498-503, 2001.

35. J.R. Coast, H.C. Haverkamp, C.M. Finkbone, and R.A. Herb. Pulmonary effects of exercise and voluntary hyperpnea simulating exercise. Int J Sports Med 20: 470-475, 1999.