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TMP Seminar Series
March 17 at 12:10 pm – 1:10 pm PDT
Presented by Washington State University – Department of Translational Medicine & Physiology
Big Data Visualization and Mouse Models of Cancer
March 17, 2026
12:10 – 1:10 p.m. PDT
SAC 147 or Zoom
Meeting ID: 982 4105 6768
Passcode: 760156
Speaker
Eric C Holland, MD, PhD
Professor of Neurological Surgery, University of Washington School of Medicine
Senior Vice President and Director Human Biology Division, Fred Hutch
Member Immunotherapy Integrated Research Center (IIRC), Fred Hutch
Endowed Chair in Cancer Biology, Fred Hutch
Pigott Family Endowed Chair
Dr. Eric Holland is a world-renowned physician-scientist who combines compassionate patient care with exacting laboratory research to discover more effective treatments for brain tumors. As a neurosurgeon, Dr. Holland specializes in caring for patients with glioblastomas, aggressive cancers that are the most common malignant brain tumors in adults. One of Dr. Holland’s many accomplishments is the development of mouse models of brain cancers, which researchers use to unravel tumor biology and test new therapies. His landmark work with mouse models also revealed that glioblastoma is not one but several diseases, a finding that is a first step toward tailoring treatment to individual tumors. Dr. Holland also studies the environment immediately surrounding tumor cells and how that “neighborhood” influences tumor formation and growth.
Talk Abstract
We have used RNA seq of large numbers of clinically annotated tumors to generate dimension reduced reference landscapes. These landscapes show clusters of similar tumors (subtypes) that have specific outcomes and biology based on their expression patterns. Mouse models of tumor subtypes genetically driven by the mutations found in human tumors recapitulate the expression patterns of the human diseases, and can be landed on the human reference landscapes.